Understanding possible side effects of SKYCLARYS

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Most common side effects from the clinical trial:

Elevated liver
enzymes

Headache

Nausea

Stomach pain

Tiredness

Some people also experienced diarrhea, muscle aches, and pain in the mouth, throat, or neck. These are not all the possible side effects of SKYCLARYS. Talk to your healthcare provider about the possible side effects of treatment with SKYCLARYS.

Learn more about
starting SKYCLARYS

Some patients taking SKYCLARYS in the clinical trial had an increase in liver enzymes, an increase in B-type natriuretic peptide (BNP, a protein that tells how well your heart is working), and changes in cholesterol levels.

Because of this, it is recommended that your healthcare provider check your liver function before starting treatment, for the first 3 months of treatment, and periodically throughout your treatment. Your healthcare provider will also check BNP levels and cholesterol levels before starting treatment with SKYCLARYS and will monitor you for changes in these areas periodically throughout your treatment.

Know how long side effects
might last

Most common side effects in the clinical trial were considered “transient,” meaning they typically lasted less than 35 days

These tables show how long 51 patients taking SKYCLARYS and 52 patients taking placebo experienced some of the most common side effects reported in the clinical trial.

Data shown include side effects reported in greater than or equal to 20% of trial participants after 48 weeks.* They do not include any side effects that patients may have experienced if they continued taking SKYCLARYS after the trial ended. You should be aware that side effects can occur or reoccur at any point while taking SKYCLARYS.

The “median” length of time is different than the “average” length of time. A median is the middle value in a set of data, which means exactly half of the people experienced the side effect for less time, and half of the people experienced the side effect for more time. While the median divides the data set in half, quartiles divide it into quarters. Quartile 1 is the point at which one-quarter (25%) of people experienced the side effect for less time. Quartile 3 is the point at which three-quarters (75%) of people experienced the side effect for less time.

*Safety data was collected through the follow-up visit at week 52.

Ready to talk to your doctor about whether SKYCLARYS might be right for you?

Learn more about how
SKYCLARYS is taken

Length in days of side effects reported in ≥20% of patients

ALT=alanine aminotransferase; AST=aspartate
aminotransferase.

Ready to talk to your doctor about whether SKYCLARYS might be right for you?

Learn more about how
SKYCLARYS is taken

INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS SKYCLARYS?

  • SKYCLARYS® (omaveloxolone) is used for the treatment of Friedreich ataxia in adults and children aged 16 years and older. It is not known if SKYCLARYS is safe and effective for use in children younger than 16 years of age

IMPORTANT SAFETY INFORMATION

What are the possible side effects of SKYCLARYS?

SKYCLARYS may cause serious side effects, including:

  • Increase in blood liver enzymes: Some people taking SKYCLARYS have had an increase in the level of liver enzymes in their blood. Your healthcare provider will do liver function tests
    • before you start taking SKYCLARYS
    • every month for the first 3 months after starting your treatment with SKYCLARYS
    • during certain times as needed while taking SKYCLARYS

If your liver enzymes increase, your healthcare provider may change your dose, stop treatment for some time, or completely stop treatment with SKYCLARYS.

  • Increase in a blood protein called B-Type Natriuretic Peptide (BNP). BNP tells how well your heart is working. Your healthcare provider will check your BNP levels before your treatment with SKYCLARYS. Tell your healthcare provider if you have signs and symptoms of your heart not working well such as too much fluid in your body (fluid overload). Signs and symptoms may include:
    • sudden weight gain (3 pounds or more of weight gain in 1 day, or 5 pounds or more of weight gain in 1 week)
    • swelling in your arms, hands, legs, or feet (peripheral edema)
    • fast heartbeat (palpitations)
    • shortness of breath

If you have symptoms of fluid overload that is considered a side effect of SKYCLARYS, your healthcare provider may stop treatment with SKYCLARYS.

  • Changes in cholesterol levels. Increases in low density lipoprotein cholesterol (LDL-C) or bad cholesterol and decreases in high density lipoprotein cholesterol (HDL-C) or good cholesterol have happened during treatment with SKYCLARYS. Your healthcare provider will check your cholesterol levels before and during your treatment with SKYCLARYS

The most common side effects of SKYCLARYS include: increased liver enzymes (ALT/AST), headache, nausea, stomach pain, tiredness, diarrhea, and muscle pain.

Before taking SKYCLARYS, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • have a history of heart problems, including heart failure
  • have a high level of fat in your blood (high blood cholesterol)
  • are pregnant or plan to become pregnant. It is not known if SKYCLARYS will harm your unborn baby. Women who use hormonal birth control should use another form of birth control such as a non-hormonal intrauterine system or an extra non-hormonal birth control such as condoms while using SKYCLARYS and for 28 days after stopping SKYCLARYS
  • Pregnancy exposure registry: There is a pregnancy registry for women who are pregnant and are taking SKYCLARYS. The purpose of this registry is to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself by calling 1⁠-866⁠-609-⁠1785 or by sending an email to SkyclarysPregnancySurveillance@ppd.com
  • are breastfeeding or plan to breastfeed. It is not known if SKYCLARYS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take SKYCLARYS

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements such as St. John’s Wort.

  • Taking SKYCLARYS with other medicines can cause serious side effects
  • SKYCLARYS may affect the way other medicines work, and other medicines may affect how SKYCLARYS works
  • Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine

What should I avoid while taking SKYCLARYS?

  • Do not drink grapefruit juice or eat grapefruit. These may change the amount of SKYCLARYS in your blood

These are not all the possible side effects of SKYCLARYS. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1⁠-800⁠-FDA⁠-⁠1088.

Please see full Prescribing Information, including Patient Information.

 

Intended for a US audience.

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