Find support in the FA and rare disease community

Patients featured are paid spokespersons for Biogen.

Patient and caregiver support and
advocacy groups

If you need additional support on your Friedreich ataxia (FA) journey, these
organizations may be able to help.*

Caregiver support

National Ataxia Foundation: Care Partners

NAF Care Partners provides guidance, strategies, and resources for those who provide care.

Visit NAF
Global Genes: Rare Disease Community

Global Genes is a nonprofit committed to eliminating the challenges of rare disease by providing information, resources, and connections to all communities affected by rare diseases.

Visit Global Genes
Caregiver Action Network

CAN works to improve the quality of life for family caregivers who care for loved ones with chronic conditions, disabilities, or diseases.

Visit CAN

Advocacy groups

National Ataxia Foundation

NAF specializes in improving the lives of people with ataxia, including FA, through support, education, and research.

Visit NAF
Friedreich’s Ataxia Research Alliance

FARA is dedicated to the pursuit of research to find treatments and a cure for FA.

Visit FARA
National Organizations for Rare Disorders

NORD helps elevate care, advances research, and drives policy change to support and empower people living with rare diseases.

Visit NORD

*This list may not be inclusive of all the organizations that support the Friedreich ataxia community.

INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS SKYCLARYS?

  • SKYCLARYS® (omaveloxolone) is used for the treatment of Friedreich ataxia in adults and children aged 16 years and older. It is not known if SKYCLARYS is safe and effective for use in children younger than 16 years of age

IMPORTANT SAFETY INFORMATION

What are the possible side effects of SKYCLARYS?

SKYCLARYS may cause serious side effects, including:

  • Increase in blood liver enzymes: Some people taking SKYCLARYS have had an increase in the level of liver enzymes in their blood. Your healthcare provider will do liver function tests
    • before you start taking SKYCLARYS
    • every month for the first 3 months after starting your treatment with SKYCLARYS
    • during certain times as needed while taking SKYCLARYS

If your liver enzymes increase, your healthcare provider may change your dose, stop treatment for some time, or completely stop treatment with SKYCLARYS.

  • Increase in a blood protein called B-Type Natriuretic Peptide (BNP). BNP tells how well your heart is working. Your healthcare provider will check your BNP levels before your treatment with SKYCLARYS. Tell your healthcare provider if you have signs and symptoms of your heart not working well such as too much fluid in your body (fluid overload). Signs and symptoms may include:
    • sudden weight gain (3 pounds or more of weight gain in 1 day, or 5 pounds or more of weight gain in 1 week)
    • swelling in your arms, hands, legs, or feet (peripheral edema)
    • fast heartbeat (palpitations)
    • shortness of breath

If you have symptoms of fluid overload that is considered a side effect of SKYCLARYS, your healthcare provider may stop treatment with SKYCLARYS.

  • Changes in cholesterol levels. Increases in low density lipoprotein cholesterol (LDL-C) or bad cholesterol and decreases in high density lipoprotein cholesterol (HDL-C) or good cholesterol have happened during treatment with SKYCLARYS. Your healthcare provider will check your cholesterol levels before and during your treatment with SKYCLARYS

The most common side effects of SKYCLARYS include: increased liver enzymes (ALT/AST), headache, nausea, stomach pain, tiredness, diarrhea, and muscle pain.

Before taking SKYCLARYS, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • have a history of heart problems, including heart failure
  • have a high level of fat in your blood (high blood cholesterol)
  • are pregnant or plan to become pregnant. It is not known if SKYCLARYS will harm your unborn baby. Women who use hormonal birth control should use another form of birth control such as a non-hormonal intrauterine system or an extra non-hormonal birth control such as condoms while using SKYCLARYS and for 28 days after stopping SKYCLARYS
  • Pregnancy exposure registry: There is a pregnancy registry for women who are pregnant and are taking SKYCLARYS. The purpose of this registry is to collect information about the health of you and your baby. Your healthcare provider can enroll you or you may enroll yourself by calling 1⁠-866⁠-609-⁠1785 or by sending an email to SkyclarysPregnancySurveillance@ppd.com
  • are breastfeeding or plan to breastfeed. It is not known if SKYCLARYS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take SKYCLARYS

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements such as St. John’s Wort.

  • Taking SKYCLARYS with other medicines can cause serious side effects
  • SKYCLARYS may affect the way other medicines work, and other medicines may affect how SKYCLARYS works
  • Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine

What should I avoid while taking SKYCLARYS?

  • Do not drink grapefruit juice or eat grapefruit. These may change the amount of SKYCLARYS in your blood

These are not all the possible side effects of SKYCLARYS. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1⁠-800⁠-FDA⁠-⁠1088.

Please see full Prescribing Information, including Patient Information.

 

Intended for a US audience.

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SKY-US-0872 05/25