SKYCLARYS patient resources
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Reata REACH
A resource to help guide you and your doctor through your prescription process and treatment journey
Visit REACH -
Patient brochure
Get additional information about SKYCLARYS
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FAQ/
discussion guideWrite down what’s most important to you and discuss it at your next appointment
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Dosing and adverse effects guide
Get more details about how SKYCLARYS should be taken, as well as its possible side effects

Patient webcast
Matt lives with FA. Hear him discuss his journey over the years and share his thoughts on SKYCLARYS

Community resources* Find support in the ataxia community
Here are a few organizations created specifically for people and families living with ataxia. These groups have resources available for patients and may provide a way to connect with others in the community.
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National Ataxia Foundation (NAF)
The NAF is an organization specializing in improving the lives of people with ataxia through support, education, and research. Resources are available to patients and caregivers to find neurologists and ataxia clinics in their area, including Ataxia Centers of Excellence (ACE).
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Friedreich’s Ataxia Research Alliance (FARA)
FARA is an organization dedicated to the pursuit of research to find treatments and a cure for FA. Patients and caregivers can connect with providers at one of their Collaborative Clinical Research Network Sites.
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Muscular Dystrophy Association (MDA)
The MDA has been committed to improving the lives of people with muscular dystrophy and other neuromuscular diseases through innovations in science and care.
Reata is independent of these organizations and assumes no responsibility for the content presented.
What is SKYCLARYS?
SKYCLARYS is used for the treatment of Friedreich ataxia in adults and children 16 years of age and older.
Before taking SKYCLARYS, tell your healthcare provider about all your medical conditions, including if you:
- have liver problems.
- have a history of heart problems, including heart failure.
- have a high level of fat in your blood (high blood cholesterol).
- are pregnant or plan to become pregnant.
- It is not known if SKYCLARYS will harm your unborn baby.
- Women who use hormonal birth control should use another form of birth control such as a non-hormonal intrauterine system or an extra non-hormonal birth control such as condoms while using SKYCLARYS and for 28 days after stopping SKYCLARYS.
- are breastfeeding or plan to breastfeed. It is not known if SKYCLARYS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take SKYCLARYS.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medications interact with SKYCLARYS. Keep a list of your medicines to show to your healthcare provider and pharmacist when you get a new medicine.
What are the possible side effects of SKYCLARYS?
SKYCLARYS may cause serious side effects, including:
- increase in blood liver enzymes. Some people taking SKYCLARYS have had an increase in
the level of liver enzymes in their blood. Your healthcare provider will do liver function tests
- before you start taking SKYCLARYS
- every month for the first 3 months after starting your treatment with SKYCLARYS
- during certain times as needed while taking SKYCLARYS
If your liver enzymes increase, your healthcare provider may change your dose during treatment, stop treatment for some time, or completely stop treatment with SKYCLARYS.
- increase in a blood protein called B-Type Natriuretic Peptide (BNP). BNP tells how
well your heart is
working. Your healthcare provider will check your BNP levels before your treatment with SKYCLARYS. Tell
your healthcare provider if you have signs and symptoms of your heart not working well such as too much
fluid in your body (fluid overload). Signs and symptoms may include:
- sudden weight gain (3 pounds or more of weight gain in 1 day, or 5 pounds or more of weight gain in 1 week)
- swelling in your arms, hands, legs, or feet (peripheral edema)
- fast heartbeat (palpitations)
- shortness of breath
If you have symptoms of fluid overload that is considered a side effect of SKYCLARYS, your healthcare provider may stop treatment with SKYCLARYS.
- changes in cholesterol levels. Increases in low density lipoprotein cholesterol (LDL-C) or bad cholesterol and decreases in high density lipoprotein cholesterol (HDL-C) or good cholesterol have happened during treatment with SKYCLARYS.
Your healthcare provider will check your cholesterol levels before and during your treatment with SKYCLARYS.
The most common side effects of SKYCLARYS include:
- increased liver enzymes (ALT/AST)
- headache
- nausea
- stomach pain
- tiredness
- diarrhea
- muscle pain
These are not all the possible side effects of SKYCLARYS. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Reata Pharmaceuticals, Inc., at 1-800-314-3934.
For additional information about SKYCLARYS, please see the full Prescribing Information and Patient Product Information.
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